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GSK3-mediated phosphorylation can render substrates as targets for proteasomal destruction, thus inactivating various oncogenic proteins, such as -catenin and c-Myc, to suppress tumor development 11

10.1038/s41419-021-04078-9 77 MetroG.FabiA.MirriM

Any unused portion must be discarded immediately

Hypoxia plays a critical role in cancer progression via increasing angiogenesis, glycolysis, apoptotic resistance, therapy resistance, genomic instability, and tumor invasion/metastasis (46)