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MDPI Full Text Scientific Reports (Nature)

Experimental application must remain within controlled, in vitro environments

Although ORD studies of polypeptides and proteins were conducted prior to CD, the dominance of ORD lasted only a few years, as in 1960, a French group presented an innovative approach to measure CD based on the use of a Pockels cell as an electro-optic retardation modulator (Grosjean and Legrand, 1960), which in combination with the adoption of the photoelastic modulator in 1966 ( An advantage of CD in the analysis of protein structure is determined by the ability of this technique to provide complementary structural information from different spectral regions (Kelly et al., 2005)