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This effect is potentially mediated through the activation of the Nrf2 pathway, which plays a pivotal role in mitigating oxidative stressa major factor in dopaminergic neuron degeneration (Ko and Attenberger, 2024)

Preclinical evaluation of the reliability of a 50 MeV racetrack microtron

Franklin Lakes, NJ): FITC (fluorescein isothiocyanate)-conjugated anti-CD41 [integrin IIb, megakaryocyte, 1.25 g/mL], FITC-conjugated anti-CD71 [Transferrin receptor protein 1, 0.65 g/mL], PE (phycoerythrin)-conjugated anti-CD61 [integrin 3, megakaryocyte, 2.5 g/mL], 7-AAD (7-amino-actinomycin D) (Biolegend, San Diego, CA) was used for dead cell exclusion

Each 8mg vial is produced under controlled cleanroom conditions, lyophilized from a stabilized buffer, and lot-coded so investigators can correlate every experimental result to a specific certificate of analysis

10.1016/j.neurobiolaging.2019.11.004 46 BorkentJ.IoannouM.LamanJ