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The elevated antioxidant capacity driven by persistent NRF2 activation and enhanced glutathione (GSH) and thioredoxin (TRX) systems enables cancer cells to withstand endogenous oxidative stress and promotes metastatic behavior

[DOI] [PubMed] [Google Scholar] 161.Callegari A., Liu Y., White C.C., Chait A., Gough P., Raines E.W., Cox D., Kavanagh T.J., Rosenfeld M.E

Ettinger, A

[13] Dosing at night is thought to mimic the natural physiologic rhythm, as endogenous GH release is highest during sleep

doi:10.1097/QAD.0000000000003965

Anisimov VN, Khavinson VKh, Provinciali M, Alimova IN, Baturin DA, Popovich IG, Zabezhinski MA, Imyanitov EN, Mancini R, Franceschi C