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For example but not for limitation, if a collection of human VH CDR sequences have carboxy-terminal amino acids which are either Tyr, Val, Phe, or Asp, then the pool(s) of synthetic CDR oligonucleotide sequences are designed to allow the carboxy-terminal CDR residue to be any of these amino acids

It is also worth noting that patients with one confirmed autoimmune condition are at significantly elevated risk for developing additional autoimmune diseases

It has been shown that baicalensis strongly prevented hepatic fibrosis by activating ERK-p53 pathways, which in turn induced G2/M cell cycle arrest and activated caspases in hepatic stellate cells (HSCs) (Pan et al., 2015)

and optineurin (OPTN), a mitophagy receptor with mutant isoforms observed in glaucoma patients (Rezaie et al., 2002)

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