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Folate depletion changes gene expression of fatty acid metabolism, DNA synthesis, and circadian cycle in male mice

While it may indirectly support metabolic health through gut repair, MOTS-c is far more effective for fat loss due to its direct activation of the AMPK pathway and fat oxidation processes

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Briefly, WT and Alas1 KO brown adipocytes were differentiated in media supplemented with vehicle or L-valine and L-isoleucine to achieve a concentration 10 times higher than the concentrations found in DMEM