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Peripheral 5-hydroxytryptamine (serotonin, 5-HT) is a cytoprotective neurotransmitter which is also involved in the hepatic physiological and pathological process

Mechanisms underlying drug-induced ototoxicity The possible mechanisms by which ototoxic agents can influence auditory function are nerve demyelination, apoptosis via caspase cascade, glutamate toxicity, ROS overload, DNA/RNA damage, inhibition of mitochondrial protein synthesis, inner ear hypo-perfusion and ion disturbance on the background of gene mutations, and increased permeability of triggered drugs (Fig

TEMUL, a sub-study of HOPE, provided free tenofovir alafenamide (TAF) for 2 years

Lees et al., 1988

, 18 , 424-431, Zharikov, A

In these patients, measuring an ammonia level has value as there is a much more linear relationship between ammonia levels and degree of hepatic encephalopathy in these patients