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A biotin deficiency can lead to brittle hair and nails

10.5483/bmbrep.2007.40.1.088 46 SuzukiM.BetsuyakuT.ItoY.NagaiK.NasuharaY.KagaK.et al (2008)

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One crucial signaling pathway activated by PRRs is the canonical NF-B pathway, which plays a significant role in the induction of pro-inflammatory cytokines, chemokines, and other inflammatory mediators in various innate immune cell types