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The human microbiome plays key roles in development, immunity, and nutrition

Signif Bioeng Biosci 2:196200

The central role of mitochondrial dysfunction in PD As the energy and metabolic hub of cells, mitochondrial dysfunction is a core feature of the pathophysiology of PD [17]

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The literature further indicates that the simultaneous intake of acidsuppressing medications (such as proton pump inhibitors [PPIs] and histamine 2 receptor antagonists [H2RAs]) with metformin increases the risk of vitamin B12 deficiency in individuals with T2D [44-48]

However, at 48 h, the proactive group showed a greater increase in serum sodium levels compared to the reactive group (10.3 [SD 3.6] mmol/L vs