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There are unexplained episodic high freezing temperature INPs over marine regions 70 , and the highly ice-active enzyme RuBisCO may partially account for these high freezing temperatures

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Evidence indicated that the dysregulation in mitochondrial function would have negative effects on the both hemostasis of cellular ions and the stability of the cellular membrane, leading to cortex excitability(29, 30)

Its broad usefulness in the repairing of damage caused by free radicals explains why its also referred to as the master antioxidant

It makes B12 a less likely cause and points you toward the next one, often thyroid function, which causes the same kind of washed-out fatigue

[DOI] [PubMed] Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M, et al