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Our results demonstrated that only fard-1 and dhs-25 mutant animals, display higher sensitivity to the ferroptosis inducer DEM, increased lipid peroxidation, anticipated drop in total glutathione and reduced lifespan, compared to wild-type, confirming their involvement in ferroptosis-aging association (Figure 4 and 5)

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Life 15(7):1081 Houghton CA (2019) Sulforaphane: its coming of age as a clinically relevant nutraceutical in the prevention and treatment of chronic disease

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Traditional in vitro models lack the complexity of the native nasal epithelium, while animal models exhibit significant anatomical and physiological differences from humans, limiting their translational value