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It is conceivable that active disruption of the myelin sheath and death of myelin-producing oligodendrocytes, infiltrating inflammatory cells, and the release of heme (by increased expression of heme oxygenase-1 (HMOX1), data not shown) could drive disruption of iron homeostasis

Mazurakova A, Koklesova L, Samec M, Kudela E, Kajo K, Skuciova V, et al

This figure illustrates the timing of changes in the number of brain synapses, cerebral blood flow, and metabolism (blue) and in brain myelination (green)

Acknowledgements This work was partially supported by the National Natural Science Foundation of China (32371461), Gusu Leading Talent Program for Innovation and Entrepreneurship (Grant No

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However, in rare cases, symptoms like insomnia or anxiety may linger longer