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Chronic hyperglycemia damages the small blood vessels supplying peripheral nerves (vasa nervorum), creating ischemic nerve injury that begins in the longest nerves first those reaching the toes and gradually spreads proximally in a stocking-glove distribution

Since its very hard to get an accurate measure of B12 in people, the researchers instead searched for levels of methylmalonic acid (MMA) as its levels rise when B12 levels decrease

*Correspondence: Ogugua Ndili Obi, [email protected] ORCID: Ogugua Ndili Obi, orcid.org/0000-0002-4692-1345

GLUTATHIONE A potent antioxidant that helps target photoaging, oxidative stress, and reduces the concerns associated with exposure to free radicals

Based on GLP-1 nasal delivery research, intranasal retatrutide would likely require daily or multiple-times-daily administration

a, b, c Harden, J