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Accordingly, preclinical data correlate the environmental disruption of the biological clock, due to shift work and light exposure at night, with hormone-dependent cancers, such as breast and prostate cancer 100,101,102

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The treatment plates included NGA with 0.5 % (v/v) DMSO (vehicle control, Ctl), 250 M SIH, or 200 M Lip-1 (as described above)

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The systemic response initiates with a rapid increase of pro-inflammatory components (IL-6, IL-8), which in turn generates an anti-inflammatory feedback by increasing the release of interleukin (IL)-10 and interleukin (IL)-1 receptor antagonist [70]

Nakajima, A