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Another randomized controlled trial showed that adding Bevacizumab to fluorouracil and leucovorin improved PFS in patients with mCRC for whom first-line irinotecan was judged inappropriate due to their poor functional status [81]

The oxidized form (GSSG) has already "spent" its electron and is inactive until the body recycles it

(ii) copper-induced ROS formation and the oxidative modification of low-density lipoprotein cholesterol facilitate the development of atherosclerotic plaques (El-Hajjar et al., 2022[129])

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