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Flossmann, O

Laboratory investigations demonstrate that CJC-1295 administration in research models influences lean tissue mass during caloric restriction while affecting adipose tissue metabolism, providing data on tissue composition regulation

In LRP1-deficient mice with IPAH and PASMCs from IPAH patients, treatment with pioglitazone activates PPAR, allowing it to bind to Smad2 and compensate for the lack of LRP1 408 (Table 1)