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doi: 10.1016/j.plaphy.2013.07.004 90 JingY

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Small, 1.5-cm plastic cylinders, 1-cm diameter, were fashioned and placed on the base of their tails in order to prevent the mice from successfully climb their tails, as the C57BL/6 mice are notorious for climbing during the test [62]

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While it doesn't necessarily ruin the product, it indicates degradation, so airless pump packaging is highly recommended