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ER translocation of the MAPK pathway drives therapy resistance in BRAF-mutant melanoma

10.1016/j.bbmt.2018.09.003 145 MohammedM

Other notable effects include: Downregulated glucocorticoid production, which helps reduce bodily inflammation

Cells overcome this oxidative stress via anti-oxidant defence mechanisms that include Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx), Catalase (CAT), Glutathione (GSH), and peroxiredoxins