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Back to Journals Drug Design, Development and Therapy Volume 10 Effects of renal function on pharmacokinetics and pharmacodynamics of lesinurad in adult volunteers Authors Gillen M, Valdez S, Zhou D, Kerr B, Lee CA, Shen Z Received 17 August 2016 Accepted for publication 6 October 2016 Published 1 November 2016 Volume 2016:10 Pages 35553562 DOI Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Sukesh Voruganti Michael Gillen, 1 Shakti Valdez, 2 Dongmei Zhou, 2 Bradley Kerr, 2 Caroline A Lee, 2 Zancong Shen 2 1 AstraZeneca LP, Gaithersburg, MD, 2 Ardea Biosciences, Inc., San Diego, CA, USA Introduction: Lesinurad is a selective uric acid reabsorption inhibitor approved for the treatment of gout in combination with a xanthine oxidase inhibitor (XOI) in patients who have not achieved target serum uric acid (sUA) levels with an XOI alone