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Description

After the first clinical report of APAP toxicity [22], investigators at the US National Institute of Health developed a mouse model of APAP-induced hepatotoxicity, which mimicked the serious liver injury observed in humans [79]

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In brief, individual organs were homogenized in MEM containing 2% NCS and the homogenate was centrifuged at 3,000 g for 15 min at 4 C

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