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Bailey HH, Ripple G, Tutsch KD, Arzoomanian RZ, Alberti D, Feierabend C et al

Moreover, ATRA activates the Nrf2-based pathway, as well as enhances skin resilience to oxidative stress by preventing Nrf2 degradation and modulating genes involved in antioxidant defense, such as SOD and CAT 181

These cellular effects are the net result of specific distortions and unwinding in DNA induced by the alkylating or platinating drug and resultant coordinated assembly of distinct proteins at the DNA damage site to activate a number of signal transduction pathways

This supports smoother skin texture and a more refined appearance, contributing to a whitening and brightening effect

We highly appreciated the expertise provided by the sequencing facility at the Institute of Clinical Molecular Biology (IKMB) in Kiel, Germany