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doi: 10.3389/fmicb.2011.00015 121 SmirnovaE.GriparicL.ShurlandD

Cadmium reduces adipocyte size and expression levels of adiponectin and Peg1/Mest in adipose tissue

The impairment of mitochondrial function caused by linoleic acid, a fatty acid that accumulates in NAFLD, leads to greater oxidative damage than that caused by other free fatty acids, such as palmitic acid, and contributes to the selective depletion of intrahepatic CD4 + T lymphocytes

Additionally, STING also induces the activation of IKK, leading to the nuclear entry of nuclear factor-B (NF-B) and subsequent the expression of inflammatory factors ( Figure 1 ) (16, 17)

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Kitchlu A, VTCE S, Anand S, Kala J, Abudayyeh A, Inker LA, Rosner MH, Karam S, Gudsoorkar P, Gupta S, Chen S, Klomjit N, Leung N, Milanez T, Motwani SS, Khalid SB, Srinivasan V, Wanchoo R, Beumer JH, Liu G, Tannir NM , Orchanian-Cheff A, Geng Y, Herrmann SM