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In addition, these studies often focused on the cortex and subcortical regions such as the basal ganglia and thalamus

[PubMed: 11477092] 126

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This reduced effect may be explained by the predominant presence of GluN1-GluN2A-GluN2B tri-heteromeric NMDAR in the hippocampus of neonatal and adult mice ( Another notable difference with the recombinant receptor experiments was evident when analyzing spontaneous activity of hippocampal neuronal cultures: the inactivation kinetics of the EPSCs did not appear to be affected by EAR-20, in contrast to the observed in expression systems where deactivation was clearly slowed

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In a mouse model of heart ischemiareperfusion, ALT-2074 was shown to have a protective effect (Blum et al