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Endogenous defense activators The NRF2/KEAP1 pathway boosts the cells inducible antioxidant defenses, which is especially useful under chronic, low-grade oxidative stress

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In LC, Plin2 drives NSCLC proliferation by inhibiting autophagy via AKT/mTOR activation (41), whereas circFAM190B propels tumor progression by suppressing autophagy through the SFN/mTOR/ULK1 axis (42)

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