(5) Autism spectrum disorders (ASDs) Numerous lines of evidence suggest that periconceptional folic acid intake reduces the risk of ASD by 40%
It is important to take these tablets as prescribed as otherwise there is a risk of developing drug resistance if you have your injection outside of the dosing window
Generally, very low levels indicate deficiency, whilst borderline results may require further investigation Holotranscobalamin (active B12): Used by some UK laboratories as a first-line or second-line test, measuring the biologically active fraction of B12 [11] [12] Full blood count (FBC): May reveal macrocytic anaemia (enlarged red blood cells) characteristic of B12 deficiency Serum folate: Usually checked concurrently as deficiencies can coexist Additional tests if diagnosis is uncertain may include methylmalonic acid and homocysteine levels, which become elevated in B12 deficiency Investigating the underlying cause is essential and may involve: Intrinsic factor antibodies: Specific but not highly sensitive for pernicious anaemia [14] [15] Gastric parietal cell antibodies: Less specific but can support diagnosis when positive Assessment for malabsorption disorders Dietary evaluation, particularly in vegans or those with restricted diets It is important not to start B12 supplements before testing, as this can interfere with accurate diagnosis
Case example : A patient receives domiciliary, rest home or custodial care visits (new and established patient)
Specific congenital deficits in the metabolism of cobalamins and/or their transporters
As always, speak with your physician regarding any medical concerns or changes to your treatment plan
