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doi: 10.1093/toxsci/kfz077

When BH 4 is deficient, eNOS becomes uncoupledinstead of producing NO, it generates superoxide (O 2 - ), a type of ROS (Kuzkaya et al., 2003)

This location suggests that nodules are the result of phonotrauma, the physical stresses on the vocal fold occurring with heavy voice use or voice use under adverse circumstances