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Formerly known as manic-depressive illness, this disorder involves episodes of depression and mania (extremely high energy and elevated mood)

J Neurosci Res 68(2):213225 Correia AS, Vale N (2024) Advancements exploring major depressive disorder: insights on oxidative stress, serotonin metabolism, BDNF, HPA Axis dysfunction, and pharmacotherapy advances

GSK3-mediated phosphorylation can render substrates as targets for proteasomal destruction, thus inactivating various oncogenic proteins, such as -catenin and c-Myc, to suppress tumor development 11

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Loschen G, Floh L, Chance B (1971) Respiratory chain linked H(2)O(2) production in pigeon heart mitochondria

BM-MSCs transplantation could benefit mitochondrial and induce mitochondrial transfer to rescue protect renal TECs, by inhibiting apoptosis and improved morphology, of tubular basement membrane and brush border structure