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Isatuximab is approved in various countries in combination with pomalidomide and dexamethasone (Pd) for RRMM patients ( 2 prior therapy lines), based on the ICARIA-MM study

Preclinical models used oral dosing at 50100mg/kg body weight, but human-equivalent subcutaneous protocols typically range from 30mg to 50mg per injection, administered once daily

Many people dont absorb B12 as well when taken orally

Exendin-4 (exenatide), for example, shows greater beta-arrestin recruitment relative to cAMP signaling compared to native GLP-1, while semaglutide shows relatively balanced signaling

Much of the observed benefit in MIC programmes plausibly comes from the programme, not the vial