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Pharmacology 401 k Paracetamol NAPQI Glutathione COX3 Poisoning Antidote AcetylCysteine GLYAT deficiency protects against acetaminophen induced liver injury by increasing glycine availability for glutathione synthesis ScienceDirect Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem Acetaminophen metabolism and production of toxic metabolite (Courtesy Download Scientific Diagram Acetaminophen induces liver injury and depletes glutathione in mice brain: Prevention by Moringa oleifera extract ScienceDirect Acetaminophen or Tylenol Toxicity Lect 19 Pharmacology
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