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Effect of glutathione depletion on Glutathione S-Transferase and Glutathione reductase activities In view of the major changes induced DEM but not BSO on cell proliferation we determine GST and GR activity in 3T3 fibroblasts (table 1 and table 2, respectively, supplementary data)

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decreased appetite Mouth sores or throat soreness Tiredness or weakness Hand-foot syndrome (tender, red, or peeling skin on palms and soles) Skin dryness, rash, or itching Nail changes (brittle, darkened, or ridged nails) Hair thinning or hair loss Headache or trouble sleeping Changes in taste Eye irritation or watery eyes Back, bone, joint, or muscle pain Flushing or feeling warm Stomach pain, constipation, or cramps Weight loss Last reviewed: 2025-12-15