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Similarly, efforts to genetically engineer NK cells are being pursued to better combat immunosuppression induced by cancer cells and the TME [11,12,13]

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In addition to its antimicrobial activity, RIF promotes liver metabolism by activating hepatic cytochrome P450 enzymes, such as CYP2D6 and CYP3A4, thereby accelerating the drug metabolism and clearance by the liver (167)

[Updated 2023 Jul 17]

1) Reveal the hypoxia mechanism of RA tissues and cells: Through single-cell sequencing, proteomics, and gene knockout technology, the interaction mechanism of HIF-1 on downstream signaling pathways and its temporal and spatial dynamic changes in the hypoxic microenvironment of RA was deeply explored, which provided a new perspective and new ideas for the development of new diagnostic biomarkers and the determination of new therapeutic targets