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Storage Requirements Lyophilized (Powder) Form: Store at 2-8C (refrigerated) for optimal stability Can be stored at room temperature (20-25C) for short periods Protect from light and moisture Shelf life typically 2-3 years when properly stored Cagrilintide 10mg should remain sealed until ready for reconstitution Reconstituted Solution: Store at 2-8C (refrigerated) immediately after reconstitution Use within 28 days of reconstitution Do not freeze Protect from light Discard if solution becomes cloudy or discolored Reconstitution Protocol Standard Reconstitution Steps: Prepare materials Cagrilintide vial, bacteriostatic water, alcohol swabs, syringes Clean vial tops Wipe both vials with alcohol swabs Draw bacteriostatic water Typically 2-4 mL depending on desired concentration Add to peptide vial Inject slowly down the side of the vial (not directly onto powder) Gentle mixing Swirl gently

PMID 33159471

Sufficient daily cobalt intake is estimated to be between 0.1ppm and 0.3ppm

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During the preparation of this manuscript, the sequence of the clinical molecule, ALRN-6924 (Sulanemadlin, MP-4897), was disclosed as Ac-LTF(R8)EYWAQL(S5)AAAAA(dA)-NH 2 (staple between R8 and S5) 25