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Experimentally, when retinoic acid, the most active metabolite of vitamin A, is administered in noise-exposed mice, it protects the cochlea by reducing significantly the apoptosis of hair cells and consequently, inducing a faster recovery of the auditory thresholds when compared to untreated animals (Ahn et al., 2020)

But conversely, the endocytosis and degradation of modified albumin is increased by GP18/GP30 (another membrane-associated albumin binding protein (36), both of which are similarly expressed in heart, liver, spleen and numerous other tissues (35)

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Notably, a neutralizing antibody MHM6 inhibited the secretion of TNF- induced by AIMP1 via competing with IgE for binding to CD23, suggesting that the interaction between AIMP1 and CD23 in monocytes might play an important role in autoimmune diseases

As an active component of celastrus and triperygium, celastrol exhibits significant broad-spectrum anticancer activities for the treatment of various cancers

contributed to the conception and design of the study