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This post is focused specifically on the decision itself

Mice were sacrificed 24 hours post-LPS administration

Lactate Dehydrogenase (LDH) Assay The relative amounts of LDH released into the media (conducted in triplicates for each group) were determined using CytoTox-ONE Homogeneous Membrane Integrity Assay kit Cat.#G7892 (Promega, USA) according to the manufacturers instructions

These molecules can be derived from natural sources, including food, venoms, and marine organisms [16, 17], or synthesized through enzymatic hydrolysis and recombinant DNA technologies [18]

By blocking both type I and type II 5-alpha reductase enzymes (compared to finasteride which only blocks type II), dutasteride provides more complete androgen suppression at the follicle level

A "natural" origin of a substance tells you nothing about overall safety at a synthetic dose, by an unphysiological route, in a manufactured form whose purity is not independently verified