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Unlike earlier compounds that affected multiple methyltransferases, 5-amino-1MQ demonstrates remarkable specificity for NNMT without inhibiting related SAM-dependent enzymes or components of the NAD+ salvage pathway

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(2013) Cell , 155(7): 16241638 Landmark study demonstrating that declining NAD+ with age disrupts nuclear-mitochondrial communication, creating a pseudohypoxic state in ageing muscle