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This structural destabilization activates the CREB3ARF4mediated Golgi stress response, which upregulates pro-inflammatory and pro-apoptotic genes including CHOP, thereby exacerbating cellular injury

In hyperosmolarity-induced DED corneal epithelial cells, AST increased the expression of ferritin to promote iron storage and reduce Fe 2+ overload

Based on current evidence, N-acetylcysteine (NAC) is the best-studied precursor and has some clinical data supporting liver health, though it is important to note that NAC is not recommended by NICE for NAFLD and should be considered only as a potential adjunct after discussion with your GP or a clinician