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The inflammatory cytokines secreted by aging cells (SASP) induce macrophage proliferation and enhance CD38-dependent NADase activity, thereby reducing the level of NAD in tissues

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Animal evidence is much larger and has been the basis for almost all of the published mechanism work

Similar content being viewed by others Introduction In the last decade, it has emerged that intestinal permeability may be a risk factor for cardiometabolic diseases, contributing to inflammatory sequalae and subsequent disease progression [1]