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Preferably 45 hours during waking hours

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2d, e), two common pro-inflammatory cytokines secreted by anti-inflammatory (M1) macrophages

optionally substituted polyether, aryl having 6 to 10 ring atoms, C3-C8 cycloalkyl, heterocycloalkyl having 3 to 10 ring atoms, heteroaryl having 5 to 10 ring atoms, and any combination thereof,said alkyl and alkenyl being optionally interrupted by one or more heteroatom or chemical groups selected from -O-, -S-, -C(O)-, -NR"-, -C(O)NR"-, -NR"-C(O)-, -NR"-C(O)-NR-, -NR"-C(O)-O-, -O-C(O)NR"- and triazole,R" and R being independently selected from H and C1-C6 alkyl,and pharmaceutically acceptable salts thereof