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Description

In the present study, we found that BSO treatment reduces GSH levels not only in whole-cell lysates but also in crude microsomal fractions, supporting a global shift in cellular redox status

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This was related to insulins ability to induce GCLC expression (GCLM was unchanged as in hepatocytes)

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Acetaldehyde is further metabolized into acetate by mitochondrial acetaldehyde dehydrogenase 2 (ALDH2) and cytosolic aldehyde dehydrogenase (ALDH1) [18]

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Liver biopsy: A method that provides a clear diagnosis or can be used to differentiate from other conditions with similar symptoms

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The role of GPX4 in the effectiveness of platinum-based chemotherapy or ICI treatment is unclear

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