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FerroOrange staining Splenic CD11c + cells (1.5 10 5 cells) were incubated with 200 L of the 5 mol/L FerroOrange (346-09531

This process is caused by glucose deprivation-induced disulfide stress and was first described by cancer researchers

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The coupling of A-GSH targeting ligands resulted in significantly higher BBB penetrations for the 3-PLG-dopa-A-GSH nanocarriers both in the presence of organoids from healthy (3-PLG-dopa-A-GSH P app : 6.52 10 6 cm/s) and PD cells (3-PLG-dopa-A-GSH P app : 6.80 10 6 cm/s) compared to the permeability values of non-targeted formulations

Glutathione: Metabolism, transport and effects of selective modifications of cellular glutathione levels

But we can draw some clear conclusions