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Consequently, the active pursuit of anti-fibrotic therapeutic agents holds significant importance

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Sirtuins are a class of nutrient-sensitive epigenetic information regulators, including in promoting mammalian health, modulating cellular senescence and lifespan, and Sirt1 is called the longevity gene

doi: 10.1016/j.jaccas.2019.12.013 575 BenjaminEJBlahaMJChiuveSECushmanMDasSRDeoRet al

More importantly, combined with in vitro experiments, the study systematically investigated the effects of AS-IV on proliferation, migration, invasion, cell cycle, apoptosis, and the expression of key genes and proteins in HepG2 and Huh7 cells (Zhou, 2022)

10 However, it is noteworthy that this treatment did not have any marked effects on reproductive performance, milk yield, or other health variables