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Only enrichment of pathways related to the mitochondrial electron transport chain (ETC), assembly of respiratory chain complexes, and protein translation in the metformin compared to placebo subgroups occurred over the duration of drug therapy from D0 to D3 post-vaccination (Fig

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Chen J, Lau YF, Lamirande EW, Paddock CD, Bartlett JH, Zaki SR

Mechanistically, ketamine may preferentially inhibit NMDARs on GABAergic interneurons, enhancing cortical excitation [207], which likely explains its neuroplasticity-enhancing effects [16]