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The NF-kappa B signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation

These patches may appear as freckles or larger, irregularly bordered dark spots known as macules

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Although most kids have goiter, they commonly dont experience any symptoms

Limitations and strengths of the study and future research A key limitation of this study is the relatively small sample size