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As Rho GTPases need isoprenylation to properly function, their activity essentially depends on the HMGCR enzyme, thus providing a critical link between the MVA pathway and tumor cell metabolism

Ovatodiolide isolated from anisomeles indica induces cell cycle g2/m arrest and apoptosis via a ros-dependent atm/atr signaling pathways

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Frequently occurring skin features, apart from the skin fragility ( n = 14) and laxity/hyperextensibility ( n = 15), included soft and doughy skin texture ( n = 12), increased palmar wrinkling ( n = 6), and atrophic scarring ( n = 5)

IMA Fungus 11(1):10