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Low oxidative stress levels induce Nrf2,164 whereas intermediate levels of ROS trigger an inflammatory response through the activation of NF-kB and AP-1

EPAS1 and VEGFA gene variants are related to the symptoms of acute mountain sickness in Chinese Han population: a cross-sectional study

Similarly, L-carnitine has been demonstrated in experiments to protect mice from the development of NAFLD through antioxidant and lipid metabolism reprogramming, but the specific mechanism still needs to be clarified [70]

Iron has also been reported to participate in the regulation of tricarboxylic acid cycle in macrophages, which further modulated the production of inflammatory cytokines (118)

indeed, it has been suggested to be suitable and advantageous for wide use in agriculture (Li et al., 2021a)

These nontargeting sgRNA sequences for generating Control-KO cells (5-CGCAGTCATTCGATAGGAAT-3) (Shalem et al, 2014), UBQLN2 (5-CGCGGTGCCCGAGAACAGCT-3), and UBQLN1 (5-GACATTAGCAACGGAAGCCC-3) were inserted into the BsmbI sites of a lentiCRISPRv2-blast plasmid (Addgene, Watertown, MA, USA plasmid 83480) using standard techniques