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In states of obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and reducing NAD+ availability [2]

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Animal studies have shown a suppression of autophagy in activated microglia and infiltrating macrophages following TBI (Hegdekar et al., 2023)

This protocol is not suitable for people who do not absorb the vitamin well for any reason (macro doses should be used)