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Alterations in microbial communities and their metabolites have been linked to key pathological features of PCOS (116, 117), including insulin resistance, hyperandrogenism, and chronic low-grade inflammation, supporting the concept of a gutmetabolismreproductive axis in which intestinal microbial ecosystems influence both metabolic and endocrine homeostasis (73)

Therefore, the analysis was performed using a random-effects model with the REML (Restricted Maximum Likelihood) estimator, which provides a more conservative and appropriate pooled effect when variability across studies is expected

Integr Biol 2:326337 Le Joncour V, Laakkonen P (2018) Seek & Destroy, use of targeting peptides for cancer detection and drug delivery

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