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MOR are also present in the superficial layers of the dorsal horn of the spinal cord (Besse et al., The distribution of KOR demonstrates some of the most striking species differences among the OR types

Unfortunately, despite the remarkable progress in preclinical studies, research on these targets and signaling pathways has mainly remained in the animal and cellular experiments stage and has not yet entered the clinical trials stage

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The antibodies utilized in this experiment are listed in Table S2 (Additional file 1)

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