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Mechanisms underlying chemotherapy-induced neurotoxicity and the potential for neuroprotective strategies

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Meanwhile, complement factor C3 deficiency attenuates arterial thrombosis in mice due to the disruption of the C3a-C3a receptor axis in platelets (113)

Ligands for Toll-like receptors (TLR) or other pattern recognition receptors (PRR) function, in fact, as very powerful stimuli for cytokine expression in neutrophils 4,5,6,7

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For example, due to unfavorable pharmacological properties, sulfasalazine treatment does not result in better outcomes in PhaseI/II clinical trials