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reactive proteostasis: a functional continuum Rather than acting as isolated modules, proteostasis pathways operate along a functional continuum that spans proactive maintenance and reactive stress responses

When is the treatment required

A critical analysis

When expressed in mammalian cells, Ec STH, and a mitochondrially targeted version (mito Ec STH), robustly elevated the NADH/NAD + ratio in a compartment-specific manner

However, patients still reported challenges such as higher diet costs, lack of family support, difficulties during holiday meals and social events, and the exclusion of favorite foods like fruit [123]

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